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Creating a healthier, more resilient garden is easier than ever. We’ve gathered a selection of 18 plants that are naturally resistant to diseases and thrive with low maintenance.

These hardy plants offer reliable, beautiful blooms without requiring much care. Disease can quickly deplete a plant’s nutrients, leading to decline, but choosing disease-resistant varieties helps prevent this. These tough plants can withstand challenging conditions like drought and harsh weather while remaining disease-free. Here are the best disease-resistant plants to grow in your garden.

1. Black-eyed Susan (Rudbeckia hirta)

black eye susan
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Black-eyed Susan is a beautiful flowering plant derived from North American wildflowers. This gives it excellent disease resistance and it will thrive in zones 3-9. Black-eyed Susan reaches 2-3 feet in height and prefers full sun and well-drained soil. 

2. Purple Coneflower (Echinacea purpurea)

Echinacea flowers
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This hardy perennial plant features large, daisy-like flowers with purple petals and a spiky, coppery-orange center. It grows 2-4 feet tall and will produce spectacular blooms from early summer through to late fall. Purple coneflower plants prefer full sun to partial shade and are ideal for USDA zones 3-9.

3. Bee Balm (Monarda didyma)

Tall red flowers of Monard bee balm in the summer garden
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Bee balm is a great landscaping plant, producing mounds of foliage topped with vibrant red, pink, or purple tubular flowers. This perennial herb prefers full sun to part shade and moist, well-drained soil, thriving in USDA zones 4-9. It can spread vigorously in the right conditions, so may need to be kept in check.

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4. Blazing Star (Liatris spicata)

wildflower garden with blazing star
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With its tall spikes of purple flowers, the blazing star is a low-maintenance plant that is rarely troubled by pests or diseases. It grows 2-4 feet tall and prefers full sun and well-drained soil.

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5. Blue False Indigo (Baptisia australis)

Baptisia australis, commonly known as blue wild indigo or blue false indigo, is a flowering plant in the family Fabaceae (legumes).
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Blue False Indigo thrives in full sun or partial shade, producing long spears of blue pea-like flowers in late spring. This perennial bushy plant grows to around 4 feet tall and prefers well-drained soil.

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6. New England Aster (Symphyotrichum novae-angliae)

aster flower
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New England Aster is a great choice for gardeners who struggle with clay soil and excessive rainfall. Bearing bright purple or pink flowers with yellow centers, this bushy perennial is not only disease-resistant but also highly attractive to bees, butterflies, and other beneficial insects.

7. Butterfly Weed (Asclepias tuberosa)

The Butterfly weed (Asclepias tuberosa) growing in the garden and flowering with wide umbels of orange flowers in summer
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As the name suggests, the bright orange flowers of butterfly weed attract butterflies and other insects. This small perennial plant forms clumps of attractive foliage and grows best in full sun in well-drained soil.

8. Hollow Joe-Pye Weed (Eutrochium purpureum)

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Hollow Joe-Pye weed is a disease-resistant perennial plant that produces clusters of pinkish-purple flowers. It grows up to 7 feet tall and prefers moist, well-drained soil in full sun to part shade.

9. Coral Bells (Heuchera spp.)

Coral bells flowers in the field
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Coral bells are a low-growing perennial plant that produces mounds of colorful leaves and delicate spikes of bell-shaped flowers that attract pollinating insects. This hardy plant rarely suffers from disease and grows best in shaded woodland gardens.

10. Penstemon (Penstemon digitalis)

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A popular choice for water-wise gardeners, penstemon plants bear tall spikes of tubular white or pink flowers atop delicate green foliage. This perennial will cope with full sun or partial shade and requires minimal water once established.

11. Lavender (Lavandula)

lavender in field
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With its striking purple color and soothing aroma, lavender attracts butterflies and is perfect for low-maintenance gardens. It thrives in sunlight with minimal water, keeps deer at bay, and fills the garden with a wonderful scent. It’s perfect for easy-care gardens while keeping the deer away.

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12. Eastern Red Columbine (Aquilegia canadensis)

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Eastern red columbines are becoming a popular choice for rain gardens, where plants are grown specifically to manage rainwater runoff. Producing tall spikes of red and yellow bell-shaped flowers throughout the spring and summer, this disease-resistant plant is the ideal choice for zones 3-8.

13. Cardinal Flower (Lobelia cardinalis)

Cardinal flower (lobelia cardinalis) flower
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With its tall spikes of striking red flowers, cardinal flowers are the perfect disease-resistant plant for shaded corners of your garden. This hardy perennial produces mounds of evergreen leaves through the winter and grows to 2-4 feet tall every summer.

14. Creeping Phlox (Phlox subulata)

Creeping phlox (Phlox subulata), also known as the moss phlox.
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Creeping phlox is a low-growing plant that produces masses of small, colorful flowers. It spreads to form a dense mat and can tolerate light foot traffic, making it the perfect disease-resistant ground cover plant for pathways and rocky gardens.

15. Prairie Smoke (Geum triflorum)

Prairie Smoke Avens (Geum triflorum) Flowers
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Prairie smoke gets its name from its wispy seed heads, giving the appearance of smoke drifting across the grassy plains. This perennial plant bears delicate nodding pink flowers and grows best in full sun or partial shade in zones 3-7.

16. Yarrow (Achillea millefolium)

Flowering yarrow, Achillea, close up
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Yarrow is a drought-tolerant herbaceous plant that bears clusters of small white, pink, or yellow flowers. It grows 1-3 feet tall and will thrive in poor soil in a sunny location.

17. Goldenrod (Solidago spp.)

looming goldenrod. Solidago, or goldenrods, is a genus of flowering plants in the aster family, Asteraceae
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Goldenrod is one of those rare plants that can thrive in almost any type of soil, provided it gets enough sun. This disease-resistant native plant grows up to 5 feet tall and produces clusters of small yellow flowers.

18. Blanket Flower (Gaillardia spp.)

blanket flower
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Blanket flower is a low-growing plant that produces a carpet of bright red and yellow daisy-like flowers. This perennial beauty thrives in zones 3-10 and will bloom throughout summer.

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climbing red roses
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oversized planters
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